Adrenogenital Syndrome
نویسنده
چکیده
The adrenogenital syndrom e is a result of the deficiency of one of the enzymes involved in the pathway leading to the synthesis of cortisol by the adrenal cortex. Laboratory evaluation of the adrenogenital syndrome involves m easurem ent of horm ones and metabolites accum ulated prior to the enzymic block as well as hormones whose synthesis is affected by deficiency of a specific enzyme. Laboratory m easurem ents of horm one metabolites in urine, because of their nonspecificity, lack of sensitivity, and m ultiple assay steps resulting in poor yield, have been supplanted by specific and sensitive radioimmunoassays of steroid hormones in plasma. In the laboratory evaluation of the adrenogenital syndrom e, problem s involved in some of the immunoassays of selected hormones should be addressed. Variables owing to specimen collection, storage and handling, and the assay itself should be minimized and controlled.
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